DUVYZAT protects from Duchenne progression
The clinical trial measured whether DUVYZAT + steroids more effectively preserved muscle strength and function than steroids alone (placebo). See more about the trial >
Completed 4-stair climb 1.78 seconds faster
than participants taking steroids alone, demonstrating significant protection.*
*This was measured by the average time it took participants in both groups to climb 4 stairs at the end of 18 months.
Additional measurements of protection
After 18 months, participants taking DUVYZAT + steroids:
-
Maintained motor function abilities longer compared with those who took placebo, based on North Star Ambulatory Assessment (NSAA) scores
- Those who took DUVYZAT + steroids saw an average of 1.91 fewer points of decline on the NSAA than those who took just placebo
-
Maintained more ability to bend their elbow or straighten their knee, a measure of muscle strength
In this study, people taking DUVYZAT showed improvements in NSAA scores and flexibility. While these results are encouraging, this analysis wasn't able to confirm that improvements were the result of treatment.
How DUVYZAT was studied
The clinical trial was 18 months long
- During the trial, the DUVYZAT dose was based on weight and was reduced if certain side effects occurred
- The effectiveness of DUVYZAT was studied in 120 participants
- The safety of DUVYZAT was studied in 179 participants
SEE WHAT THE RESEARCHERS LOOKED AT
4-stair climb
How fast participants could climb 4 stairs before and after 18 months of using DUVYZAT and steroids, compared with steroids alone
NSAA‡
Participants' mobility and muscle function across multiple muscle groups as measured by the NSAA
Muscle strength
A muscle strength test that included how well participants could bend their elbow and straighten their knee
Fat tissue
How much fat was in the muscle, a measurement of muscle loss
How It Works