Proven to protect muscle strength and function

DUVYZAT was studied in one of the largest Duchenne clinical trials to date

18 months long
Participants received steroids along with either DUVYZAT or placebo
Included 179 participants* with a wide range of genetic variations of Duchenne

^*The median age was 9.8 years, meaning that half the participants were younger than 9.8 years old, and half were older.

Ryan, taking DUVYZAT for 4+ years.

A clinical trial is a research study that tests new medicines to make sure they are safe and effective.

SEE WHAT THE RESEARCHERS LOOKED AT

4-stair climb

How fast participants could climb 4 stairs before and after 18 months of using DUVYZAT and steroids, compared to steroids alone

NSAA^†

Participants' mobility and muscle function across multiple muscle groups as measured by the North Star Ambulatory Assessment (NSAA)

Muscle strength

A muscle strength test that included how well participants could bend their elbow and straighten their knee

Fat tissue

How much muscle was preserved compared to replaced by fat, a measurement of muscle loss

^†The NSAA is a test that helps healthcare providers understand how well people with Duchenne can move and do daily activities by watching them perform specific tasks.

Dive image — Ryan, taking DUVYZAT for 4+ years.

DUVYZAT protects from Duchenne progression

In the clinical trial, DUVYZAT and steroids were more effective at preserving muscle strength and function than steroids alone.

DUVYZAT helped maintain muscle strength and motor function about

BETTER THAN USING STEROIDS ALONE^‡

^‡As measured by the mean change in time from baseline to 18 months of 4-stair climb in DUVYZAT vs steroids alone (placebo).

More measurements of protection^§

After 18 months, participants taking DUVYZAT and steroids:

Maintained motor function abilities longer compared to those who took placebo, based on NSAA scores
Maintained more ability to bend their elbow or straighten their knee, a measure of muscle strength

DUVYZAT also reduced how much muscle was replaced by fat, a measurement of muscle preservation.

^§After clinical trials, researchers use statistics to see if the results are really from the new medicine and not just by chance. In this trial, people taking DUVYZAT showed improvements in NSAA scores and muscle flexibility. However, the analysis wasn't able to prove that these results were due to the treatment.

Possible side effects of DUVYZAT

DUVYZAT was studied in multiple clinical trials involving 222 participants, many of whom were taking DUVYZAT for more than 2 years. Talk to your healthcare provider about how best to manage side effects if they do occur.

Most common side effects in the phase 3 clinical trial^∥

Diarrhea (37%)
Abdominal pain (34%)
Low platelet levels (33%)
Nausea/vomiting (32%)
High triglyceride levels (23%)
Elevated temperature/fever (13%)

For patients who experienced diarrhea, it usually occurred in the first few weeks of treatment. Most of the time it was mild and manageable. Very few people had severe cases. Only one person needed to pause their treatment due to diarrhea, but no one stopped taking DUVYZAT because of it

^∥Experienced by ≥10% of participants.

Your healthcare provider will monitor you or your loved one for changes in blood counts.

If side effects occur, your healthcare provider can adjust the dose to help reduce them.

Talk to your healthcare provider about trying DUVYZAT today.

How It Works Taking DUVYZAT

Proven to protect muscle strength and function